Rational design of balanced dual-targeting antibiotics with limited resistance
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چکیده
منابع مشابه
Rational design of azepane-glycoside antibiotics targeting the bacterial ribosome.
RNA recognition by natural aminoglycoside antibiotics depends on the 2-deoxystreptamine (2-DOS) scaffold which participates in specific hydrogen bonds with the ribosomal decoding-site target. Three-dimensional structure information has been used for the design of azepane-monoglycosides, building blocks for novel antibiotics in which 2-DOS is replaced by a heterocyclic scaffold. Azepane-glycosid...
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ژورنال
عنوان ژورنال: PLOS Biology
سال: 2020
ISSN: 1545-7885
DOI: 10.1371/journal.pbio.3000819